Light-Emitting-Diode-Based Multispectral Photoacoustic Computed Tomography System

Light-Emitting-Diode-Based Multispectral Photoacoustic Computed Tomography System

Blog Article

Photoacoustic computed tomography (PACT) has been widely explored for non-ionizing functional and molecular imaging of humans and small animals.In order for light to penetrate deep inside tissue, a bulky and high-cost tunable laser is typically used.Light-emitting diodes (LEDs) have recently emerged as cost-effective and portable alternative illumination sources for photoacoustic imaging.In this study, we have developed a portable, low-cost, five-dimensional (x, y, z, t, λ ) PACT system using multi-wavelength LED excitation to enable similar SUPER GOO functional and molecular imaging capabilities as standard tunable lasers.Four LED arrays and a linear ultrasound transducer detector array are housed in a hollow cylindrical geometry that rotates 360 degrees to allow multiple projections through the subject of interest placed inside the cylinder.

The structural, functional, and molecular imaging capabilities of the LED−PACT system are validated using various tissue-mimicking phantom studies.The axial, lateral, and elevational resolutions of the system at 2.3 cm depth are estimated as 0.12 mm, 0.3 mm, and 2.

1 mm, respectively.Spectrally unmixed photoacoustic contrasts from tubes filled with oxy- and deoxy-hemoglobin, indocyanine green, methylene blue, and melanin molecules demonstrate the multispectral molecular imaging capabilities of the system.Human-finger-mimicking phantoms made of a bone and blood tubes show structural and functional oxygen saturation imaging capabilities.Together, these results demonstrate the potential of the proposed LED-based, low-cost, portable PACT system Arch Door Mirror for pre-clinical and clinical applications.